MRPS12 anticorps

N° du produit ABIN6566989

Cet anticorps Lapin Polyclonal détecte spécifiquement MRPS12 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MRPS12 anticorps (ABIN6566989)

Antigène: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRPS12 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MRPS12 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human MRPS12

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MRPS12

Antigène: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Autre désignation: MRPS12

Sujet:

Synonyms: 28S ribosomal protein S12,28S ribosomal protein S12 mitochondrial,mitochondrial,Mitochondrial ribosomal protein S12,MRP-S12,MRPS12,MT-RPS12,RPMS12,RPS12,RPSM12,RT12,S12mt

Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein.

Poids moléculaire:

Observed_MW: 14kDa

Calculated_MW: 15kDa

ID gène: 6183

UniProt: O15235

Pathways: Sensory Perception of Sound